DISCRETE BIOCHEMICAL SYSTEMS THEORY

Discrete Biochemical Systems Theory

Almost every biomedical systems analysis requires early decisions regarding the choice of the most suitable representations to be used.De facto the most prevalent choice is a system of ordinary differential equations (ODEs).This framework is very popular because it is flexible and fairly easy to use.It is also supported by an enormous array of stan

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Operant Self-medication for Assessment of Spontaneous Pain Relief and Drug Abuse Liability in Mouse Models of Chronic Pain

The search for safe and efficient chronic pain treatments is dampened by the lack of reliable models that faithfully reproduce current pharmacological treatments for chronic spontaneous pain in humans.Preclinical models often assess the antinociceptive efficacy of non-contingent pharmacological treatments evaluated in the short-term.Here, we provid

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Conventional Therapies Deplete Brain-Infiltrating Adaptive Immune Cells in a Mouse Model of Group 3 Medulloblastoma Implicating Myeloid Cells as Favorable Immunotherapy Targets

Medulloblastoma is the most common childhood brain cancer.Mainstay treatments of radiation and chemotherapy have not changed in decades and new treatment approaches are crucial for the improvement of clinical outcomes.To date, immunotherapies for medulloblastoma have been unsuccessful, and studies investigating the immune microenvironment of the di

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Errand Runners of Digital Platform Capitalism: The Errand Economy as a Contribution to the Discussion on the Gig Economy

This article describes a new concept called the errand economy.It examines the dark side of the platform economy and the gig economy and makes a valuable contribution to the field.The concepts, especially for liberal scholars, hide the negative impact of platform capitalism on production relationships and the working class by emphasising digital te

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